Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis
نویسندگان
چکیده
منابع مشابه
Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis.
BACKGROUND The incidence of thrombotic events increases during aging, but the mechanisms are not well understood. To investigate the prothrombotic role of oxidative stress during aging, we tested the hypothesis that aged mice overexpressing the antioxidant enzyme glutathione peroxidase-1 (Gpx1) are protected from experimental thrombosis. METHODS AND RESULTS Susceptibility to carotid artery th...
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ژورنال
عنوان ژورنال: Circulation
سال: 2013
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.112.000966